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MB710 is an aminobenzothiazole derivative which is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a K d of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines [1].


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MB-710: a p53 Y220C activators Drug, Initially developed by MRC Laboratory of Molecular Biology, Now, its global highest R&D status is Preclinical, Mechanism: p53 Y220C activators (Cellular Tumor Antigen p53 Y220C activators), Therapeutic Areas: Neoplasms, Active Indication: Neoplasms, Active Org.: MRC Laboratory of Molecular Biology.


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Cancer metastasis refers to the dissemination of cancer cells from the primary tumor to other organs via the systemic circulation, specifically a sentinel lymph node [. L929 and HCT116 cells were grown at a density of 1.0 × 10. A549, PANC-1, HCT116, and L929 cells (2 × 10) and then incubated for 24 h. The MTT solution (1 mg mL.


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MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro..


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DESCRIPTION. Titleist MB 710 Iron Set 3-PW with Steel Shafts The Titleist MB 710 Iron Set 3-PW with Steel Shafts has a uniform muscle shape behind the impact area that provides solid feel. The improved shape has a softer topline, rounder profile for a classic, but contemporary look. The constant blade length with minimal progressive offset for.


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Fast test drive de um clássico das nossa estradas , o Mercedinho 710, ano 2001COMPATILHE, DEIXE O LIKE E INSCREVA-SE


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This is a product information page introducing Mitsubishi Materials' new and existing products. Product information of CBN & PCD Insert MB710 / MB730 is available. A wide range of information on applications, use cases, types, materials, performance, etc. Please find the most suitable product.


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710 Tools - #6mmYellowPearl $13.00. Carved Pours x 710 Tools Collaboration $50.00. 710 Tools - #TheTravelMelter2 $16.50. 710 Tools brings you an array of high quality tools for connoisseurs. All of our tools are manufactured out of 403 Grade Stainless Steel. Each is crafted to meet surgical grade standards. They are built to last a lifetime.


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